A drug interaction is when one medicine affects how another medicine works in the body. Interactions can involve prescription drugs, over-the-counter medicines, supplements, herbal remedies, foods, alcohol, or medical conditions. Medscape's Drug Interaction Checker helps you build safer, more effective treatment plans by quickly identifying potential interactions between medications, supplements, and even common foods. Interactions can occur between two prescription medications, between a prescription and an over-the-counter drug, or between a drug and a food, supplement, or herbal product. Check for drug interactions and learn what drug combinations to avoid with the RxList drug interaction checker tool. Drugs.com is the most popular, comprehensive and up-to-date source of drug information online. Providing free, peer-reviewed, accurate and independent data on more than 24,000 prescription drugs, over-the-counter medicines & natural products. Drug interaction Grapefruit juice can act as an enzyme inhibitor, affecting the metabolism of drugs. In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. Check for interactions between drugs including warnings for food, alcohol, pregnancy, breastfeeding, and diseases. Switch between consumer and professional reports. Use WebMD’s Drug Interaction Checker to identify potential interactions between medications, supplements, and foods. Reduce side effects and support safer treatment decisions. Display complete list of interactions for an individual item by clicking item name. Add another item to analyze for potential interactions. NOTE: This tool does not address chemical compatibility related to I.V. drug preparation or administration. Use Drugs.com’s Drug Interaction Checker, trusted by doctors and patients, to instantly review your meds for unsafe combinations.